国产传媒

Biography

Dr. Chang is a tenured professor in the Department of Physical Therapy.  She also serves as the Department’s foundation science curriculum coordinator.  Dr. Chang graduated from the University of California, Irvine with a major in biology and minor in political science. She received her Master of Science and PhD in Neurobiology and Anatomy from The University of Rochester.  She is honored to be able to teach future health care providers the basic science knowledge necessary to succeed as a health care provider.  She applies her training as a molecular neuroscientist in her research on infantile epilepsy at the David Geffen UCLA School of Medicine, Department of Neurosurgery.  In this role she characterizes anatomical and protein markers in various forms of pediatric epilepsy such as, hemimegalencephaly, tuberous sclerosis complex , focal cortical dysplasia, and Rasmussen encephalitis.  She is also the coordinator of the UCLA Neurosurgery BioBank and the UCLA Rare Epilepsies Brain Disease Tissue Bank (REBDTB).

Courses taught at Mount Saint Mary's University

• PT 401 – Gross Anatomy (DPT program)
• PT 407 – Neuroscience (DPT program)
• BIO 50A/B Human Anatomy/Physiology (undergraduate Biology program)

Selected publications

• Leitner DF, Lin A, Sawaged Z, Kanshin E, Friedman D, Devore S, Ueberheide B, Chang JW, Mathern GW, Anink JJ, Aronica E, Wisniewski T, Devinsky O. Brain Molecular Mechanisms in Rasmussen encephalitis. Epilepsia. 2022 Nov 7. doi: 10.1111/epi.17457. PMID: 36336987 DOI: 10.1111/epi.17457
• Krawczyk MC, Haney JR, Pan L, Caneda C, Khankan, RR, Reyes SD, Chang JW, Morselli M, Vinters HV, Wang AC, Cobos, I, Gandal MJ, Bergsneider M, Kim W, Liau LM, Yong W, Jalali A, Deneen B, Grant GA, Mathern GW, Fallah A, Zhang Y. Human Astrocytes exhibit tumor microenvironment-Age- and Sex-related transcriptome Signatures. Neurosci. 2022 Jan 5. doi: 10.1523/JNEUROSCI.0407-21.
• Chang JW, Reyes SD, Faure-Kumar E, Lam SK, Lawlor MW, Leventer RJ, Lew SM, Lockhart PJ, Pope K, Weiner HL, Salamon N, Vinters HV, Mathern GW, Fallah A, Owens GC..Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures. Front Immunol. 2021 Apr 6. DOI:
• Fallah A, Subramaniam T, Phillips HW, Michalet X, Vinters HV, Yong WH, Wu JY, Salamon N, Ellingson BM, Wang AC, Reyes SD, Ibrahim GM, Weil AG, Chang JW, Babayan D, Nguyen JC, Behnke E, Tseng CH, Mathern GW. Novel tonometer device distinguishes brain stiffness in epilepsy surgery. Sci Rep 2020;10(1). doi: 10.1038/s41598-020-77888-0.
• Owens, GC, Garcia AJ, Mochizuki, AY, Chang JW, Reyes SD, Salamon N, Prins RM, Mathern GW, and Fallah A. Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients. Frontiers in Immunology. 2019;10:121. DOI: 10.3389/fimmu.2019.00121
• Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Does Adult Neurogenesis persist in the Human Hippocampus? Cell Stem Cell. 2018 Dec 6;23(6):780-781. doi: 10.1016/j.stem.2018.11.006
• Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Human Hippocampal Neurogenesis drops sharply in children to undetectable levels in adults. Nature. 2018;555(7696):377-381. doi: 10.1038/nature25975.

Selected scientific presentations

• K, Magaki S, Diaz R, Williams CK, Dewar S, Chang J, Vossel K, Engel Jr J, Vinters HV. Alzheimer disease pathologic changes in temporal lobectomies for epilepsy. UCLA Pathology Department Research Day. May 20, 2022.